Andrea Nicolini's Unimap
Dr. Nicolini graduated (summa cum laude) at School of Medicine,
University of Pisa in 1974. He received postgraduate diplomas at
University of Pisa in Internal Medicine (1980), Pneumology (1984), and
Medicine (1986). His research interests
include breast and gastrointestinal cancer and their metastases, tumour
markers, post-operative follow-up, physiopathology, immunology and
immunotherapy of cancer, and thyroid tumours.
Since 1975 he has contributed to research in neuroendocrinology and
thyroid physiopathology. Additionally, he has worked on a study aimed
at distinguishing benign from malignant thyroid tumors by fine needle
aspiration and biopsy (FNA, FNB). Later, this research has had further
developments with studies on galectin. The achieved results have
permitted to better select patients with malignant thyroid nodules who
surgery, hence reducing the number of undetected malignant cases.
From 1978 to nowadays, Dr. Nicolini is the principal investigator of a
clinical research aimed at defining the usefulness of serum tumor
markers for early detection and treatment of distant metastases from
breast and colorectal cancer. Methods and diagnostic accuracy of
different serum tumor markers have been examined. The accuracy of
instrumental examinations has been evaluated too. The scope of this
research is to offer to patients a post-operative follow-up with high
During last decade, his research has been mainly devoted to
immunology: specifically, the evaluation of immunogical parameters
lymphocytes and subsets, cytokines and growth factors) both in healthy
subjects, and in breast cancer and in endocrine dependent metastatic
breast cancer patients treated with hormone-immunotherapy. Based
upon the results of this research, an interpretative model of the
relationships between immune system and tumor cell biology has been
proposed. The same model has also been applied to better comprehend
the improved clinical outcome obtained in gastrointestinal cancer
patients at high risk of relapse.
- Advanced (post-graduate) course on Internal Medicine and Medical
- Advanced (post-graduate) course on Clinical Oncology,
- Advanced (post-graduate) course on Endocrine Oncology,
- Graduate course on Medical Oncology.
Recognitions, Honors, and Awards:
- Fellowships from Commission of the European Communities as part
of the project "Europe against cancer" 1992; FIRC 1993, 1994; ISPO 1994.
- Member of Editorial and Advisory Board for
International Journals with impact factor in the field of oncology.
- Member of European Group on Tumour Markers (EGTM) Board,
International Society of Oncology and Biomarkers (ISOBM) Board, and
European Society for Cancer Immunology and Immunotherapy.
- Nicolini A, Carpi A, Rossi G. "An immunotherapy schedule in
endocrine-dependent metastatic breast cancer: correlation between
clinical course and immunological parameters", J Immunother 2005, 28 (3): 276-279.
- Nicolini A, Carpi A, "Beta-interferon
and interleukin-2 prolong more than three times the survival of 26
consecutive endocrine dependent breast cancer patients with distant
metastases: an exploratory trial"; Biomed Pharmacother, 2005 Jun;
- Nicolini A, Carpi A, Rossi G. "Cytokines in
breast cancer"; Cytokine Growth
Factor Rev 2006;
- Nicolini A, Carpi A. "Immune
manipulation of advanced breast
cancer: an interpretative model of the relationship between immune
system and tumour cell biology", Medicinal
Research Reviews, 2008, Dec 22.